Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) long intergenic non-protein coding RNA 540 (LINC00540) URS000075ACCF_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

LINC00540: LINC00540 is a long noncoding RNA (lncRNA) that has been identified as a risk locus for abdominal aortic aneurysm (AAA) in several genome-wide association studies (GWAS) [PMC7027016] [PMC9075263] [PMC8489199] [PMC6788446]. AAA is characterized by chronic inflammation, vascular smooth muscle cell apoptosis, and extracellular matrix remodeling and degradation, with inflammation being strongly associated with AAA progression [PMC7783286]. Macrophages in the media and adventitia of the aorta play a role in AAA formation by producing matrix metalloproteinases (MMPs), reactive oxygen species, and inflammatory factors [PMC7783286]. Previous studies have also identified lifestyle factors such as smoking history and cholesterol levels as risk factors for AAA development [PMC7783286]. In addition to LINC00540, other risk loci associated with AAA include SMYD2, PCIF1/MMP9/ZNF335, and ERG [PMC7027016] [PMC8489199] [PMC6788446]. These loci implicate cell cycle regulation, inflammation, cholesterol metabolism, and extracellular matrix breakdown in the development of AAA. Furthermore, multivariate Cox analysis has identified LINC00540 as one of the genes significantly correlated with overall survival in acute myeloid leukemia (AML) patients. However, its impact on AML prognosis is poor. The function of LINC00540 is currently unknown but it has been suggested to be associated with FGF9 expression within AAA tissue. Overall, LINC00540 is an important genetic factor associated with the development of AAA.

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences
AGGGGCUGGGCGGGCCGGCCCAGGGCCUGCCUAUGGCCUGAAAGAGAAAACCUGCCACGGAGCCCGGGCUUCUCUGAUCCUCCCGCCAAACUUUGUCUCUCAUUUAGCUUUCUUUGUGUCUGAGGAUUUAGCAAAGGCCUCAGGGAUUCAACAGAGUUGGAUUGCUGAGAAUAAAAUUACGGAUUUCUCCAUAAUGGACACACGCACUUUUUGUUUGUGCUGUUUCCUUUAGAAUGGACGAUGAGUCAAAAUUGUUCGUUUAUGCUUCUUCACAGAAGGAUCUUCUGUGUCGUAGGAGGUGGCCUGCAGCAAUCUGGACAUUCAGUGGUCCUCCUGUGAUUAAUAGGUGAACGGAUGAGCUAUUCUGAUAAGAACUGGGGAACUUUUGCCAUUCAAAAGCAAAUAGAAGAACUGGGAGAUUCCUCAACUUAGCUUUUCUUUUUUUUGGUUCUAAAGUGACUGCGAAUGGAGGUAGAAGAGAAGAAAAGCUUUCAAAAACAUCUUCCAUUAAGAAAAAUAUGUAUCUUCAUGAAGACCUAUCUGAGUAAAAUUACUAAAACAUAAUGGCUUUCUUGAAAUAGAAUGGAAUGAAAGGCAUAUUAGGGAGUAUGAAAGUAUGAAGAUUUUAUUAACAUACUUCUAGAAGUUUAUUAAAUAUCUGCACAGGAACUGUAAUUUGAGAUCAGUGGUGGAAAGAGAAUAAAGGAAUCACGUGGACAUCAGCUCUGAGGCCUGUGGCCCCACUUGCUUCUGGGCUUUCUAUAGACAUUUGCUGGUGACCUGCCCAGGCAGGCUAGAGUACCCUUCCUCAUUGCACCCUGUGUUCCCAUCCUCUUUUCCUUCCUUCCUUCCUUCCUUCCUUCCUUCCUUCCUUUCUUCCUCCAUCCCUUAUGAAACCCUCGUUGUGCAGUUACUUAUUAGGUGCUGUGUGAGCGUCUGAAGUCUCCCCUCACCCACUUUUCCAUUUGGGCCACUUGGCCAGUGAUUGCAUCAGUACCAGGGUUCUAGGAGCCAUGCAGGGAUCCCCAGUGGGCAGAGCUGGCCGUAGCAUUUGGAAAGGAAGAGAGAGAACUGGAGACAAUGCCUAGGAACAAAAGCAGAGUCCAGACCCAGGCAUCAAGUGCAAAUCCAAAGGCUCUGGAUGAGUCAGUUCCCAGCAAAGGGACACAAGUAGGCACAGAAGGAAGGACAGCAGAAAACACUGGUCCAGAGAGGGCCUGCAGAGCCAGAAGCGAUGACGCAUCCAAGGUUGUGUUUGACUUCUGCACUGCCUCUGCAACCUGUAAGCACAUCUGAGCCAGUUCAGAAAGUAGGAAAACCAAAGUAUAUCAGAAAUGGCCUCUUAUCAUCAAGGAGAUUUUGGUCUAGAUUGCUUAUUGCUCAGGAGAAAUCACCACUUUUUAAAAAGAUAUGCUGAGAUAGGGUUUAGUUGGGAUAGAAAAGGUUAUUAAACUACGGGACACCCUUCCUUUACAGAGUGUAAGCACUACUACCCCUUUUGUUUGUCUGUUUUUCUUAUUUUUCUCACAGAUGCAGUUCCUGCAUUAGUAUUGAUAAAUGUGUGGCUGCUCCACUUGGAGUGUUUUCAAAGCAUAAAUCACAGCAUUGAUGGUGCUGUGGUUUGGCUCUUCCAGCCCUCUUAACAACGGUCUGAUGGACUUGGCGAGAGUCUAGCCACGUGUUCUGGCCUCUGUCACUCUCAUGGCUGAAACGCAUGCACACCCACAGAUGGGGGCCCCGUGGUAGAGAUGUGCCUCUACUUGUCAAAUAGACUGACUCCAAAUUCGGAAAUAUGCCUCAGGAAUCUAGAAAGAUAGAAAAGGAGUCUUCGUCACUGUAGGGUCUCAUUCACAAUAUGGAGGAGAGAUGGAGGGGAGUUUUUGGUAUAAAUUUUGCCUCAUAAAAAUUCUCCACGUUGUUUUGUACUGUAUGAGGGUAGCGAGAAAUUAGUUGAUGGUUAACAAUCAAGCUGGAGAAGAAUAUCCUCAAUUUUUCACAUGGAAAAUGAAAAACUACAACUCCUUCCAAAUAUAUGUAUGUUUCUUUUCUGAAGAUAGACGUGUGUGUGUUUGUGUGUAUCAUAUAACAUUUAUUUUUUGAUUUCUUUGUUAUCAACAGUAAAAAUACAGAAAAUGAUGCCAAAAAAAAAAAAAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications