rno-mir-378b: Rno-mir-378b is a microRNA that has been implicated in the regulation of contrast-induced acute kidney injury (CI-AKI) [PMC6629072]. It has been found to be down-regulated in CI-AKI rats [PMC6629072]. The underexpression of rno-mir-378b, along with the overexpression of rno-miR-126a-5p, may be associated with kidney fibrosis and persistent renal damage in CI-AKI patients [PMC6629072]. Rno-mir-378b and other down-regulated microRNAs (rno-miR-374-5p, rno-miR-652-3p, rno-miR-187-3p, rno-miR-320-3p, and rno-miR3559) are predicted to target a group of up-regulated genes that are involved in CI-AKI pathways [PMC6629072]. These genes include Gpnmb, Lox, LOC100360679, Hcar2, Apoa4, Mat1a, Cldn22, Steap1 Gstm1 Arntl Ephx1 Cstb [PMC6629072]. Furthermore, four microRNAs (rno-miR126a5p,rnomiR3225p,rnomiR30c5p,andrnomir378b) and ten genes (Gstm1,Gpnmb,Ephx1 Arntl,Cstb,Cndpl,Ppp1r1b,Ppp1r1a,Gng7,andIrf2bp) that were found to be aberrantly expressed in CI-AKI showed consistent results between RT-qPCR and sequencing results [PMC6629072]. However,rnomir378bandmir18435pare not found in the selected databases for predicted target mRNAs of 31 microRNAs [PMC4035064]. Overall, rno-mir-378b appears to play a central role in the regulation of CI-AKI and may be a potential therapeutic target for the prevention and treatment of this condition [PMC6629072].