rno-mir-6216: Rno-mir-6216 is a microRNA that has been studied in the context of stroke. However, there is a lack of published information on its function and targets [PMC5270432]. To gain more insight, the putative targets of rno-mir-6216 were examined. One of its predicted targets is Mapk3, which is involved in the promotion of neuronal precursor cell differentiation [PMC5270432]. Interestingly, rno-mir-6216 has been found to target multiple pathways, including the vascular endothelial growth factor (VEGF) signaling pathway, suggesting its involvement in various functions related to stroke etiology [PMC5270432]. Additionally, rno-mir-6216 has direct targets within the VEGF signaling pathway [PMC5270432]. In a study investigating the effects of electroacupuncture (EA) on stroke recovery, it was found that EA can alter the expression levels of rno-mir-6216 and other miRNAs associated with cell proliferation. This may contribute to improved functional recovery and cerebral blood supply after stroke [PMC6297779] [PMC8846361]. Overall, further research is needed to fully understand the function and targets of rno-mir-6216 in stroke pathology.