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Homo sapiens (human) long intergenic non-protein coding RNA 628 (LINC00628) URS000075AA5E_9606

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LINC00628: LINC00628 is a long non-coding RNA (lncRNA) that has been studied in various cancer types. In lung cancer, transfection with LINC00628 resulted in decreased expression of LAMA3, while transfection with sh-LINC00628 led to increased expression of LAMA3 [PMC6796683]. Additionally, LINC00628 was found to be overexpressed in human lung adenocarcinoma tissues and lung adenocarcinoma cell lines [PMC6796683]. In breast cancer, low expression of LINC00628 was associated with a poor prognosis and low overall survival rate [PMC8463317]. Furthermore, overexpression of LINC00628 led to down-regulation of LRRN2 expression in MGC-803 cells [PMC4897602]. In breast cancer patients, aberrant expression of LINC00628 was significantly linked to ER expression, physical activity, diabetes disease, stress, age at menopause, and obesity. Therefore, it has been proposed as a potential biomarker for breast cancer patients [PMC8405088]. Additionally, the expression levels of LINC00628 were significantly increased in lung squamous cell carcinoma (LUSC) compared to adjacent normal tissues [PMC8721862]. Overall, these findings suggest that LINC00628 plays a role in the pathogenesis and progression of various cancers.

Genome locations

Gene Ontology annotations

Sequence

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AGCCAACUGGUUGUCUAAGGCUGGGAAGGGGUUAAGAUGCCCCCGGAGCUUGCCGCGAGGGCAGCUGCCUCAGCGGGCACUCCGCCUGGAUGGGAAUAUAAGCACUCUUGGUGUUGCCCAGGCAGAGAGGGCAGUGUGGAGGGAAGUUGCUAGAAAAAGGCAGGGGACAUAAUCCAUACUGGCCUCUUUCCCAGGCACAUCACAGUGGCAGAAUUAUUUAUGAUUCUGACCCAAUGGGGAUCCCUCUACUUGGGGAGACUGCCAACCCACGCCCUCCUGAAUGGCAACGUCCUCCCACAGAGACAGAGGGGAACAAGUAGCAUUUAUGGAGCGGCACAGAGGAAAGAGUGUGGGCUUUGGAGACAGCACAGCAGCACUCACAUCCCGGCCCAGACACUUCCUGUGUGACCUUGAGCCAGUUGAUGAACCUGUCUGGGCCUCUGUUUCCUCAUCUGUUAUCGGCGAAAAUGUUUCGGAGGACACCUAUUGUAUAAUGUUGCUAUGCAGAUUAAAUGCACUAGCAGAGGCAAAGUGCAUAGCUUAGAGGAAGGAAGUACUCGCUAAGUGGUAGCUGGUGUGAUAGGUGGGCCAAGUCCUGGCAGGAGCUGGGCUUGCUGGCUGCCCUGUUUUGCUGAAACAGCAGCAUCACCAUCAGCAGCAACUGUGGAAAUAUAGACCCUUGAUAAAUACAGGUGAAUAAAAUGAAUGAUUAGAAACUGGACCUGCCACUCUGCAGAACCCAGGCACUGCUCCCCAGCAGCUGGUGCCUCAAAGCAGCUGCUAACAUGGCAGGAGACAGUCAGACCAGCAGUGAAUAGCUAUGCUUCGUAAGACUUCAUACACAAGGCAGGCGUGUGGACUGACCAGAAAGGUGGCAGUCACUGUCCAUCAAGAGAAUCCCCACCUGUUUUCCAAUAUGUCAGCCAGGAGGCUCGCACUCCCAAAAGGAAUGUUCUCAGCCAGCUCCCUGACUGUCCCCACCUCUGACAGUGGACUCUCUUGGGUCUCUCAAAAGGCUCCUCCUCCUCAGCCAUGGGGUGAAGGAAUCCUGUUUGCCGGGGAGGCGGGAUGCUGCCCAGGGUGGCUGUUUUGGGAGAGCGAGCAGGAUGAGAUAGUGCCUAUGAGUGAUCUUUGGAGAUGGAGGUGCUAUGGCCACCUGUGGGGACUGCCUGGGUGCCUCCUGGCCACUGUCAACUUCCUUGCUCACACUGAGAUUCUGUGAUUCUCCUCUGAGCAUUUCCAUGGAUAAUUUUUUUUUUUCAGAGACACUAUUAAAGAUUUUAAAAAUUG

Taxonomic tree

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Publications