hsa-mir-8055: Hsa-mir-8055 is one of the top 10 miRNAs with the most evident differences in expression [PMC7595655]. It is involved in regulating apoptosis by targeting BCL2, FAS, TNF, and other mRNAs [PMC7595655]. In HUVECs induced by H2O2, the expression levels of hsa-mir-8055 were downregulated compared to control HUVECs, but were upregulated in HUVECs treated with vitamin C and H2O2 [PMC7595655]. It was also found to be involved in T-cell responses to specific antigens and was previously shown to be a sepsis marker [PMC7354481]. Furthermore, hsa-mir-8055 is suggested to be regulated by hsa_circ_0071542 through the interactions of a circRNA-miRNA-mRNA network [PMC8119943]. Circ_0071542 is a differentially expressed circRNA in children with fulminant myocarditis and it regulates the expression of MAPK through binding hsa-mir-8055 [PMC7354481]. In conclusion, hsa-mir-8055 is a miRNA that plays a role in apoptosis regulation and T-cell responses. Its expression levels can be influenced by oxidative stress and vitamin C treatment. Additionally, it is involved in circRNA-mediated regulation of MAPK expression. These findings highlight the importance of hsa-mir-8055 in various biological processes and its potential as a biomarker for sepsis and myocarditis.