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Homo sapiens (human) PRR34 antisense RNA 1 (PRR34-AS1) URS000075A679_9606

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PRR34-AS1: PRR34-AS1 is a long non-coding RNA (lncRNA) that has been found to play a role in hepatocellular carcinoma (HCC) cell proliferation and apoptosis [PMC8190132]. Knockdown of PRR34-AS1 was shown to decrease the expression of E2F2 and SOX12, while not affecting the expression of other mRNAs [PMC8190132]. This suggests that PRR34-AS1 specifically regulates the expression of E2F2 and SOX12 in HCC cells. Additionally, PRR34-AS1 was found to promote the nuclear translocation of β-catenin in HCC cells [PMC8190132]. The absence of PRR34-AS1 led to a reduction in nuclear β-catenin levels and an increase in cytoplasmic β-catenin levels, while overexpression of PRR34-AS1 had the opposite effect [PMC8190132]. Furthermore, PRR34-AS1 was shown to up-regulate Rab27a expression, leading to increased exosome secretion of VEGF and TGF-β in HCC cells [PMC9615160]. These exosomes were then transmitted into THLE-3 cells, promoting their malignant phenotypes [PMC9615160]. The expressions of miR-296-5p, SOX12, and E2F2 were found to be negatively correlated with miR-296-5p but positively related to PRR34-AS1 in HCC samples [PMC8190132]. This suggests that miR2965p/SOX12/E2F axis is involved in the regulation of malignant phenotypes by PRR34 long non-coding RNA antisense RNA 1 (PRR34 AS 1) in HCC cells.

Genome locations

Gene Ontology annotations

Sequence

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CGCGGAGCACGGAGGACGGGGCCGGGCGACCUGGGCACCAGCAGGACCCGAGGCCAGGAGCCAGGGGCCCAGAAGAUUGAGCUUCUAGAGCCUCAGAGAUGGAAUUCGCCGUUUUGCCGCGAUUUGGCGUUAACUUAUUGACCCAUGGGGAGGAGGGUCACUUCCCGUGAAAAGAAGGCAGAGAUGUUUUGCUGUGCCCAGUGUGAGGAAGCGAAGGAAAAGAAAGAUCUUUUGAAAAUGUGUACAUCUACUUGCAGCUUGAAAAUUCCAAGUGCCAGACAUUUUUCUUGGAGGAAAUAAAUGUCUUCAAUUUAUUCAUCUUACCUGUUGAUUAUGUUCUGUAAUGAUUUAUUUUAUAAUUUAAUCCUUGUCUAGAACCGAGGCCAUCUUUGGAAAGUAAAAGACCUAGGUCUCUUUGGUCCAGGAGACAUUGUGGCCCUCUCUUAAAAUCAUUGACUGCCGAGAUCUGGGCCCAGGCGGCUCUCGGACUGAACCGGUCUGUGCUAGGCAGCCUGGCCCACUCGGCCUUCAAAACACAAGGGAUGGGAGACAUAUGCUCGGCUCACAUCGUUUUGUUUUGAUUUAUUUUAAACUGCUUAAGAUGAUUUUAGCACAAGGAGUGGUGUAUCUUACUUGCAUUCUGAGAGCCACUGGAUUUGCAAGCUAGAGUACAAUUUUUUUUUUAAUCCAAAUUUAGAAAUUGCCUUUUAGAGUAGACAACAGCAUGCUACUUUGCCUUUUAACUCACUUUUAAAGAACGAUUCUUAAGAUCAAGUACAUUGAAUUUGGAGAUUGGUCCCCCUCCGUUAUUAGGGGCUGGAAAUGGCCCACUUUUCAAAAAUAAGGUCAGAAAAGGGGUGUUUCUGACCUAAGAGUUCUUCCAGGCUGGGCUCGUACCACAGAGAUUCUUCCACACCCAUGUCCUGAGUCCUUGUCCUACACACCAUUUUUUCUUCCAAGGAGAAGGAGUGUGGCAUUCAGUUCCAGUGUCAUCGUGUGGAAAAGAGUCCCUGCCUGGCUGAGAAACUGUCACAGGCAGCCGGGCCACUUCCCAGCAUGACCCACAAGCCCGAUGGUGCCCCUCGAAUGGUUAAGGGACCCGUACAGAUACCAUUCUUUUAAAGCAAGCCAAUGCAAUCUUCACGAAUUGCAGUUCCACCCUGGCUGCUGGUACUAACUCUAAUAAUGGAAAAAAAUUUAAAAGAUUGGGGACAACAGGAAACACAUUGGAUCCCCAGGGGAAACGGCCUGGAAGCUACAGUAGAGACAUGGGUGACCCAAGGGCUCUGUUCAAGUCCUGGGGCUGUUCCCUUUAUUCCUCCAAGCCUCAGCUCCCCGGAUUUAAAGUGAGAACAGCACCCAGCCCAGCCCACUGUCAAGGGCUGUUGCAGGAAUAUGACAACAGCCACCAAUAUUUGCAUAGCAGAGAUGCCCAGUUUCGUUUUCUAUUUGAAAGUUUCUCUGAAGGGGGAUGUGCUAGAGACACGAGAACAACUGCUACCAUCUUAAUAACUUUUCUGGCAAUACACGACGAUGAUUGUUUAUGUUAAUCUCAUAACUAUUAACAAUAAUUCAUUUCAUUCUCAUAAUGAAUUAUAUCUAUUUGACUUAUAAUAAAUAGAAUCAUAUCAGUAAAAAAAAAAAAAAAAAA

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Publications