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hsa-mir-630: Hsa-mir-630 is the most abundant extracellular miR, and it has been found to regulate airway epithelial cell death and survival, as well as maintain a complex regulation of its cell cycle and apoptotic balance [PMC5028059]. In a study, quantitative RT-PCR analyses were conducted using an ABI PRISM 7900 instrument and Assay-on-Demand TaqMan probes for Lefty1, miR-630 (hsa-mir-630), and miR-5703 [PMC4074034]. The study followed the manufacturer's protocols from Agilent Technologies for these analyses [PMC4074034].
MIR630: MIR630 is a type of microRNA that has been studied in relation to tumorigenesis. According to a study [PMC9753082], the level of MIR630 was significantly lower in both types of HO. This suggests that MIR630 may play a role in controlling tumorigenesis [PMC8744645]. In NT2/D1 cells, the expression of NANOG, OCT4, and SOX2 proteins was inhibited after transfection with MIR630 mimic compared to control cells [PMC8744645]. Specifically, the expression of NANOG was inhibited by 69%, OCT4 by 70%, and SOX2 by 32% [PMC8744645]. These findings indicate that MIR630 may have an inhibitory effect on the expression of these proteins in NT2/D1 cells [PMC8744645]. Overall, these studies suggest that MIR630 may have an important role in controlling tumorigenesis and regulating the expression of key proteins involved in pluripotency and stem cell maintenance [PMC9753082] [PMC8744645].
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