hsa-mir-4268: Hsa-mir-4268 is a microRNA that has been implicated in various biological processes and diseases. It has been shown to regulate EPHB2 expression and mediate extracellular matrix degradation through circRBM33 [PMC8603816]. Hsa-mir-4268 is found in different forms, with the 3' addition isomiR being the most frequent [PMC9226005]. Luciferase activity assays demonstrated that hsa-mir-4268 mimics decreased luciferase activity in certain groups, indicating its regulatory role [PMC8201884]. Hsa-mir-4268 has been found to target circ-G042080 and TLR4 expression, suggesting its involvement in the Toll-like receptor signaling pathway and myocardial damage associated with multiple myeloma [PMC8201884]. In MM patients, exosomes derived from MM patients led to increased levels of circ-G042080 and TLR4, while hsa-mir-4268 levels decreased [PMC8201884]. Hsa-mir-4268 has also been implicated in other diseases. It was found to have differential expression in patients with metastatic melanoma before and after surgical resection [PMC8258953]. Additionally, hsa-mir-4268 overexpression inhibited cell proliferation and induced apoptosis of gastric cancer cells, suggesting its potential role as a tumor suppressor in gastric cancer development [PMC8258953]. In a non-coding RNA network analysis, hsa_circ_0062682 was shown to closely interact with hsa-mir-4268 [PMC8258953]. Overall, hsa-mir-4268 appears to play a significant role in various biological processes and diseases.