v24

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Homo sapiens (human) long intergenic non-protein coding RNA 1644 (LINC01644) URS000075A415_9606

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LINC01644: LINC01644 is a long non-coding RNA (lncRNA) that is included in the ceRNA network in gastric cancer (GC) [PMC8479203]. In SGC-7901 cells infected with shRNA-LINC01644, the levels of LINC01644 were lower compared to nontransduced cells or cells infected with shRNA-control [PMC8479203]. LINC01644, along with LINC01697, LINC02268, and LINC01537, showed significant differences between overall survival (OS) and differentially expressed lncRNAs in the ceRNA network [PMC8479203]. Knockdown of LINC01644 and LINC01697 inhibited tumor cell proliferation in SGC-7901 cells [PMC8479203]. The mRNA expression levels of LINC01644 and LINC01697 were significantly increased in gastric cancer cells compared to normal cells [PMC8479203]. Silencing of LINC01644 and LINC01697 inhibited the proliferation of GC cells, suggesting their contribution to the pathogenesis and progression of GC as therapeutic targets [PMC8479203]. The expression levels of both lncRNAs were significantly upregulated in gastric tumor tissues compared to adjacent normal tissues [PMC8479203]. The prognostic value for survival prediction was demonstrated for both lncRNAs using multivariate cox proportional hazards regression analysis in GC patients [PMC8479203]. A two-lncRNA signature consisting of LINC01644 and LINC01697 was established as a prognostic biomarker for survival prediction in GC patients [PMC9339642]. Additionally, 16 m6A-modified lncRNAs associated with oral squamous cell carcinoma patients' survival prognosis included LincO1644 among others [PMC10111779]. References: - PMC8479203 - PMC9339642 - PMC10111779

Genome locations

Gene Ontology annotations

Sequence

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CAUGUAGCCACCUUAUCCUGCACAGGUCUGUGGCAGGCCGUGAGACGGUGACCAGAGAAGCAGUCAGCACUCACGGCCCCUGCCCUUUCAGAGUUUACGCUUGCUUGGAAGCCUCCAGAAUGGGGAUAAGCACAAGACAUUUAUGCUGGGCUUCAUCCAGGAAGCUCUGGUGGAAGGAAGAGAAAGCAGCCCACACAGCAAGGUUCAGGAGAAGAUUCCCAUGAAGGACAACUGGGGUUCAGCCCCAUCCAGCAGAUGACACGGAGCCGGCCUCGGAGGUGUCCUCACCGUGGGACACUGGCAUCUGAGCUACCUCAGGGCGUAGCCGGCCGAUGUUCCCAGCCUCCCCCUGGGCACAGCCAGCCCAGGCCAAGUGGUCUAGCCCCGGCCCCCACUCAGCAUGGCCCAAAAAAGGAGCAAAAAGCAGAAAGCUCAAGGACCCUCAGAAUCAAGUUUUGCAGAAAGACACAAAGCUCAAGAACAGAGGUGCAACUAAGGGAACACACCCUGUAAGACUGCCUCCCAGACACACCACUGCAGCCAGUGAAUUGCACUGUUUAGACUUUGACUUCAGGGUCAGGGUGAGCUGAUGAGACUGGCCCCUUGAUGAAGUAAGAGGCCACCAAGGAGUGAGAGCGGCUGAGUUUGAGCCCUGCCUCUGCCGUCUGCAACUCUCUCAUCUUGAGCAGGUCCAGCCCCAGUGUGGGCCUCAGAUCUCCCAUCCUUGAGAUGAGAGAAUUCAAAUCCAGCUCCACCUCUGCAGCCCACGCCCUUCCCCUGCACUGCAUGGCAUCCGAUAGGCUUGAAGAAGGCGUGAAUGACAUUCAAAGGGCCACAUCAUCUAAGUCGCACUCCUCUCCCAUCCCAUCCCUUGUUGUCCUUUACAUGAUUCCCAUUCAUCUUUCUUCUCUUGGGCCCAGGGGUGUGCUGGUGAAUGUUUAACAGCCACUCCAUGAAAAAAUAAAACGGUCUUGAUUGAUGGCAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications