hsa-mir-297: Hsa-mir-297 is a microRNA that plays a role in the positive regulation of miRNA-mediated repression [PMC3794589]. To investigate this phenomenon, a study analyzed the role of Pumilio proteins in miRNA-mediated repression using microarray analysis on HEK293 cells [PMC3794589]. The cells were transfected with either a negative control, hsa-mir-297, or hsa-mir-297 along with PUM1/2 double knockdown [PMC3794589]. The results of the analysis were presented in Supplementary Table S5 [PMC3794589]. In addition, the study examined the enrichment of PVT1 and hsa-mir-297 with an anti-Ago antibody compared to an anti-normal IgG antibody [PMC9008320]. The results showed that both PVT1 and hsa-mir-297 were substantially enriched with the anti-Ago antibody [PMC9008320]. This finding suggests that hsa-mir-297 is involved in miRNA-mediated repression and is associated with Ago proteins [PMC9008320]. Overall, this study provides evidence for the positive regulation of miRNA-mediated repression by Pumilio proteins and highlights the enrichment of hsa-mir-297 with Ago proteins [PMC3794589] [PMC9008320]. These findings contribute to our understanding of the regulatory mechanisms involved in miRNA-mediated repression.

MIR297: MIR297 is a miRNA that has been studied in various contexts [PMC8709190]. In vitro studies have shown that lnc-SLC15A1-1, chemokines CXCL10 and CXCL8, and miRNAs miR-150-3p, miR-27b-5p, and MIR297 play important roles [PMC8709190]. In a comparison between BPDCN and AMLTET2m, lower expression levels of CPA3, ATP8B4, SPINK2, TRGJP1, and CDK6 were observed in BPDCN while SULF2, MIR297, and miR708 were higher [PMC6898719]. Some miRNAs were not expressed using the miRNeasy extraction method including MIR297 [PMC5025515]. Upregulation of MIR297 has been found to activate NF-kB leading to increased inflammation and apoptosis [PMC9028838]. It is possible that MIR297 is controlled by SEs located near Slc39a11 in RCS cells [PMC4787819].