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hsa-mir-1231: Hsa-mir-1231 is a microRNA that has been found to play a role in various biological processes. In HBV-transfected HepG2 cells, over-expression of hsa-mir-1231 suppressed HBV replication by targeting the HBV core protein [PMC6177563]. Hsa-mir-1231 is part of a putative ceRNA network that includes three miRNAs (hsa-miR-152-3p, hsa-miR-762, and hsa-mir-1231) [PMC7202328]. This ceRNA network involves three lncRNAs (HOXD-AS2, LINC01123, and FIRRE), three miRNAs (hsa-miR-152-3p, hsa-miR-762, and hsa-mir-1231), and four genes (MED12, RHBG, NCAM1, and ARF4) [PMC7202328]. Hsa-mir-1231 has been found to be differentially expressed in various studies. For example, it was up-regulated in HBV-transfected HepG2 cells [PMC7085209] and was also differentially expressed in NHDF cell cultures treated with a biological drug [PMC5816894]. Hsa-mir-1231 has also been implicated in various diseases. In colorectal cancer (CRC), it was found to be associated with prognosis along with other miRNAs [PMC8975208]. Additionally, it was found to be located in differentially hypermethylated regions in CMML samples compared to healthy donor samples [PMC3273467]. Hsa-mir-1231 has the potential to interact with other miRNAs such as hsa-miR223 and has been implicated in the regulation of genes involved in PCOS development [PMC7497355] [PMC8350636].
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