hsa-mir-4503: Hsa-mir-4503 is a microRNA that regulates the gene MYCN [PMC8687781]. In a study, the DEM-hub gene network was analyzed, and it was found that hsa-mir-4503, along with hsa-miR-3591-5p, hsa-miR-548as-3p, and hsa-miR-206, primarily marked the prior hub genes [PMC8687781]. Among all the differentially expressed microRNAs (DEMs), six of them (hsa-miR-548as-3p, hsa-mir-4503, hsa-miR-5194, hsa-miR-3591-5p, hsa-miR206 and hsa-miR3127) consistently changed in both datasets [PMC8687781]. These six DEMs were further analyzed in subsequent analyses [PMC8687781]. Additionally, it was found that nine modified genes were regulated by the microRNAs: hsa-mir4503, hsa-miR3591–5p ,hsa–miR548as–3p ,hsa–mi R206 [PMC8687781]. The PolymiRTS algorithm predicted that a CG nucleotide transition could influence the putative binding site of hsa mir 4503 [PMC3507747]. References: [PMC8687781] - Liang Y., Li Y., Li Z., et al. (2020) Identification of key microRNAs and genes in hepatocellular carcinoma by bioinformatics analysis. Journal of Cancer Research and Therapeutics 16(6): 1394–1400. doi: 10.4103/jcrt.JCRT_100_20. [PMC3507747] - Bhattacharya A., Ziebarth J.D., Cui Y. (2014) PolymiRTS Database 3.0: linking polymorphisms in microRNA target sites with human diseases and complex traits. Nucleic Acids Research 42(Database issue): D86–D91. doi: 10.1093/nar/gkt1021.