mmu-mir-1894: Mmu-mir-1894 is a recently discovered mouse microRNA that has been found to have a potential role in tumor metastasis inhibition in breast cancer cells [PMC4849059]. In a study using mouse models, it was determined that knockdown of the target gene Trim46, which is regulated by mmu-mir-1894, was sufficient to replicate the effect of mmu-mir-1894 on breast cancer metastasis [PMC4849059]. Additionally, Trim46 was found to be involved in the proliferation and migration of human breast cancer cells [PMC4849059]. Mmu-mir-1894-3p, a mature miRNA derived from the 3'-strand of mmu-mir-1894 precursor, was identified as a tumor suppressor [PMC4849059]. Mmu-mir-1894 is located close to common sites of retroviral integrations and may have a role in cell homeostasis that requires further experimental verification [PMC4849059]. Mmu-mir-1894-3p and mmu-mir-1894-5p target different sets of genes due to their different seed sequences [PMC4849059]. Although mmu-mir-1894 has been recently discovered, its function is still poorly understood [PMC4849059]. In the study, it was found that mmu-miR-449a and mmu-miR-1894 significantly decreased lung metastasis nodules formation in mice compared to control groups [PMC4849059]. Furthermore, three microRNAs including mmu-miR449a and two others had significant effects on lung metastasis in cancer cells [PMC4849059]. The functional mature form of mmu-miR 1894 against cell proliferation and metastasis was identified as mmu mir 19894 3p[PMCID: PMC4849059]. Mmu-mir-1894 was also found to inhibit metastasis and proliferation of mouse breast cancer cells [PMC4849059].