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hsa-mir-6718: Hsa-mir-6718 is a microRNA that is downregulated in NPM1 mutated acute myeloid leukemia (AML) compared to NPM1 wild-type AML [PMC7851519]. It may also be related to DNMT3A-mutant AML patients [PMC8918330]. In a study, the concordance index of the model was 0.702, and hsa-mir-6718 was one of the nine miRNAs identified [PMC8918330]. ENCORI analysis revealed that hsa-mir-6718 had 2536 target genes [PMC8918330]. PDGFRA was identified as a common target gene of hsa-mir-6718, hsa-miR-1269b, and hsa-miR-374c, as well as five genes related to immune checkpoint genes (ICGs) [PMC8918330]. Furthermore, multivariate analysis showed that PDGFRA was downregulated by hsa-miR-374c, hsa-mir-6718, and hsa-miR-1269b in AML patients [PMC8918330].
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