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hsa-mir-890: Hsa-mir-890 is a microRNA that belongs to a cluster of miRNAs including hsa-mir-888, hsa-mir-892a, hsa-mir-892b, and hsa-mir-891a [PMC3563971]. In a study, transfection with hsa-miR-142-3p and hsa-mir-890 resulted in the absence of Occludin staining at cell junction locations while ZO-1 remained intact [PMC6174781]. These three miRNAs (hsa-miR-142-3p, hsa-miR-18b, and hsa-mir-890) may serve as indicators of functional modifications in the epithelial barrier in MetS-related fatty liver disease [PMC6174781]. Another study expressed the MetS-related miRNA trio (hsa-miR142, hsa-miR18b, and hsa-mir890) in cultured epithelial cells to investigate their impact on epithelial barriers and cell junctions [PMC6174781]. Hsa-mir890 was added to a pathway based on global miRNA profiling using Pathway Designer (IPA) [PMC6174781]. Hsa mir890 is also found in the primate X chromosome cluster of clade-specific miRNAs (hsa mir5143) [PMC3012074]. In cirrhotic livers, it was found that HSA mir890 was downregulated after TGF-beta1 treatment [PMC8351572]. HSA mir890 was also found to target GAP43 along with HSA mir3125 [PMC9837191]. Additionally, it was predicted that HSA mir890 interacts with ANXA2 mRNA using miRWalk analysis along with other miRNAs such as HSA mir206 and HSA mir155 among others [PMC5950137]. HSA mir890 is also co-deleted with SLITRK2 in a group of microRNA genes [PMC2937017]. Furthermore, HSA mir890 has been associated with mutations in inherited retinal dystrophy [PMC7648123]. Finally, HSA mir890 has been found to be overmutated in lung adenocarcinoma [PMC7648123].
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Gene Ontology annotations
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