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hsa-miR-8071: Hsa-mir-8071 is a microRNA (miRNA) that has been identified in various studies [PMC7607069] [PMC7062941] [PMC7680973] [PMC7719707] [PMC7824949] [PMC7220275] [PMC5048719] [PMC6599129]. It has been found to be co-targeted with other miRNAs, such as hsa-miR-17-5p, hsa-miR-5196-3p, and hsa-miR-18a-5p, among others [PMC7607069]. The H19 rs217727 G>A SNP has been shown to affect miRNA-lncRNA interactions and result in the formation of hsa-mir-8071 and hsa-miR-4804–5p, while destroying the binding sites of hsa-miR-3960 and hsa-mir-8071 on H19 [PMC7062941]. Hsa-mir-8071 has been found to have predictive value in identifying patients with mesial temporal lobe epilepsy (mTLE) with hippocampal sclerosis (HS) compared to healthy controls, with a sensitivity of 83.33% and specificity of 96.67% [PMC7680973]. It has also been identified as being upregulated in exosomes in the culture medium of both UVA and UVB groups, along with other miRNAs such as hsa-miR-769–5p and hsa-miR–758–3p among others[ PMC7719707]. Additionally, it has been found to be associated with various diseases such as aortic aneurysm dissection (AAAD) where it is upregulated compared to normal aortic tissues[ PMC6599129]. The rs217727 polymorphism has been linked to the levels of hsa-mir-8071 in the circulation [PMC8666442]. Overall, hsa-mir-8071 has been implicated in various biological processes and disease conditions, highlighting its potential as a biomarker and therapeutic target.
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