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hsa-mir-6775: Hsa-mir-6775 is a microRNA that is reported to silence the transcription of the alpha 7-cholinergic nicotinic receptor gene (CHRNA7) expressed on lymphocyte surface and associated with lymphocyte anergy, T regulatory cell differentiation, and immunologic tolerance, which may predispose to cancer development [PMC8288189]. In a study on papillary thyroid microcarcinoma (PTMC), the expression of hsa-mir-6775 was found to be decreased in PTMC with lymph node metastasis [PMC9281586]. The study also found that hsa_circRNA_000121 may increase the expression level of MMP-14 by downregulating the expression of hsa-mir-6775, which may play a role in PTMC invasion [PMC9281586]. However, binary logistic regression analysis showed that the expressions of hsa-mir-6775 in PTMC tissues were not significantly related to lymph node metastasis [PMC9281586]. The study also suggested that hsa_circRNA_000121 may regulate PTMC invasiveness by inhibiting the effects of hsa-miR-4763 and hsa-mir-6775 [PMC9281586]. Furthermore, it was proposed that hsa_circRNA_000121 may upregulate the expression of MMP-14 by binding to hsa-mir-6775, enhancing the aggressiveness of PTMC and leading to cervical lymph node metastasis in patients [PMC9281586].
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