v24

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Homo sapiens (human) BRAF-activated non-protein coding RNA (BANCR) URS0000759AA6_9606

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BANCR: BANCR is a long non-coding RNA (lncRNA) that has been implicated in various biological processes and diseases, including melanoma and bladder cancer [PMC6676454] [PMC9580248] [PMC4981950]. In melanoma, BANCR has been shown to promote cell proliferation through activation of the MAPK signaling pathway [PMC5672086]. Conversely, in bladder cancer, BANCR has been found to inhibit cell proliferation and induce apoptosis [PMC4981950]. BANCR has also been implicated in the regulation of lymphangiogenesis in pancreatic cancer (PC) under hypoxic conditions [PMC9580248]. In melanoma, the interaction between BANCR and LINC-PINT has been investigated, with LINC-PINT potentially inhibiting melanoma cell proliferation by downregulating BANCR through the MAPK pathway [PMC6676454]. Additionally, LINC-PINT may serve as an upstream inhibitor of BANCR in melanoma [PMC6676454]. In bladder cancer, the downregulation of BANCR is associated with activation of ERK1/2 and JNK pathways, suggesting a tumor suppressor role for BANCR in this context [PMC4981950] [PMC4072697]. Furthermore, BANCR has been shown to regulate VSMC proliferation and migration through activation of the JNK pathway [PMC5777714] [PMC9022845] [PM7695379]. Overall, these studies highlight the diverse roles of BANCR in different diseases and biological processes. Further research is needed to fully understand its mechanisms of action and potential therapeutic implications.

Genome locations

Gene Ontology annotations

Sequence

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AUUCCCUUACUUUCUUAAUAAACUCGCUUUCACUUUAUGGAUUCAACUGUAAUUCUUUCUUGUGUGAGAUCCAAGAACCUUCUUGUAGGGUCUGGAUUGGGACCCUUUUCUGGUAACAUCUUCCUGGUGACCAUGAAGGGACAAUACUGAAGAGACCCCUGACCCUAAGGAAAUAGACUGCAGCACCAAUGGGCCAACUUUGGGGCGAUCAUCUUGCCCAGAAACAUCAUGUUGAAACUCUUGGUCAGAGGUUGGAUGAAAGCUGACAGGGUCCAUCCAGGAGCAAGUUUGAGCCUUGCCAGUUCCAUUUUGGGUGCUGAGUGGAGUGGCGACUAUAGCAAACCUGUGAUCUCUGGCUGCUGCUCAGAAGAAACAAGAGGGAGGGAUGAAUAAUGUAAAACUCUGGAUCAAUAUUCUAAUUCUGAGCCUCUAUUGGAAUCAGCUAGCAACCACAUAUCAGCUUGGUUUCAACAGUUUCCCAGUUCAUGCUGCUGAGAAGUUCAGAGUCAAACCUGAAUCUCACCUCUGCAAAGAGCACAGGACUCCAUGGCAAACGUUGUAUAUACGCAAGUCAUCCCUGGCACCACAUUGAUUUACUGCACCAGGCUUUCUUCAUUGUGAUGAUGUUCUCUCUCUUUUCUAAAAAAAAAAUAAAAAUAAAAUUUAAAAAAUCCUAAAAAAAAAAAAA

Taxonomic tree

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Publications