hsa-mir-4327: Hsa-mir-4327 is a downregulated miRNA associated with spinal glioma development [PMC7640765]. It is one of the 4 downregulated miRNAs, along with hsa-miR-3154, hsa-miR-203a-3p, and hsa-miR-138-2-3p, that are associated with low-grade spinal glioma [PMC7640765]. The expression of hsa-mir-4327 was evaluated in patients with intrahepatic cholangiocarcinoma and was found to be significantly associated with overall survival [PMC7257878]. It was also found to be expressed in low levels in the sera of patients with pancreatic ductal adenocarcinoma (PDAC) and not in controls, suggesting its potential as a biomarker for this cancer type [PMC8301411]. The target genes of hsa-mir-4327 include CREBBP and IGF1R, which are involved in the FoxO signaling pathway [PMC4754688]. Additionally, the functional enrichment analysis revealed that target genes of hsa-mir-4327 are significantly related to protein binding and sequence-specific DNA binding transcription factor activity [PMC4754688]. The number of predicted target genes for hsa-mir-4327 was 131 [PMC4754688]. Overall, these findings highlight the potential role of hsa-mir-4327 as a biomarker and its involvement in various cancer-related pathways.