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MIR599: MIR599 is a microRNA that plays a role in various cellular processes. In vascular smooth muscle cells (vSMCs), MIR599 acts as a substrate for the TGFB2 transcript and is involved in the regulation of vSMC proliferation and synthesis of collagen-1, collagen-5, and proteoglycan [PMC7123062]. It also represses vSMC proliferation, migration, and the synthesis of PCNA and MKi67 proteins [PMC7123062]. However, there are contradictory findings regarding MIR599's role as an oncogene or tumor suppressor. It has been reported to be upregulated in some cases but downregulated in glioma tumors [PMC8235499]. MIR599 has also been found to be nearly non-expressed in various organs during embryonic stages [PMC7080778]. In melanoma cells, loss of miR-494 or miR-599 leads to increased expression of INPP4B and promotes cell proliferation [PMC5301276]. Additionally, circ_0000285 has been identified as a competing endogenous RNA (ceRNA) for MIR599 that regulates TGFβ2 expression [PMC7509321]. Further research is needed to understand the biogenesis of circRNA during ferroptosis and uncover the rules that control its production [PMC8026611]. Overall, MIR599 plays a complex role in cellular processes and its dysregulation can have implications in various diseases.
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