hsa-mir-601: Hsa-mir-601, identified as one of the altered miRNAs in miRCancer data mining, is a metastamiR [PMC4491873]. In a study on patients with steroid-induced osteonecrosis of the femoral head (SONFH), hsa-mir-601 was found to be upregulated in bone marrow mesenchymal stem cells (BMSCs) [PMC5887684]. The lack of information on hsa-mir-601 prompted its selection for further investigation [PMC8753100]. Furthermore, hsa-mir-601, along with hsa-miR-639, hsa-miR-520c-3p, and hsa-miR-573, exhibited specific expression profiles in a cluster of malignant and normal samples from the transition zone, distinguishing this cluster from other samples [PMC3733730].

MIR601: MIR601, along with MIR4266, MIR1251, and MIR3612, has been found to be associated with spontaneous preterm birth (sPTB) [PMC9884789]. The loading of EXOmiRNA, including miR198 and MIR601, is mediated by hnRNPA2B1 through binding to specific EXO-motifs such as GGAG [PMC8806638]. The oncogene c-Myb has been shown to bind to the promoter of MIR601 [PMC9035158]. To assess the promoter activity of MIR601, a luciferase reporter plasmid containing the MIR601 promoter sequence with a putative binding site of c-Myb was constructed [PMC9035158]. Depletion of c-Myb significantly increased the activity of the MIR601 promoter as observed in a luciferase assay [PMC9035158]. Overexpression of c-Myb repressed both the activity of the MIR601 promoter and the expression of miR-601 [PMC9035158].