hsa-mir-1253: Hsa-mir-1253 is a microRNA that has been extensively studied in various contexts. It has been found to have sequence identity to 136 plant viruses/strains, indicating its potential role in viral interactions [PMC3821693]. In addition, hsa-mir-1253 has been shown to affect gene expression in anaerobic species such as Fusobacterium nucleatum and facultative anaerobic species like Escherichia coli [PMC6702754]. It has also been implicated in various diseases and conditions. For example, hsa-mir-1253 has been found to be significantly deregulated in bone mineral density status and HIV-infected breast milk [PMC4577125] [PMC7395778]. Furthermore, hsa-mir-1253 has been associated with ERα36 encoding transcript and its expression levels have been found to be altered in multiple cancers including bladder, lung, and prostate cancer [PMC6600239] [PMC8414803]. Additionally, hsa-mir-1253 has a potential role in tumor suppression through epigenetic silencing in medulloblastoma [PMC8777531]. It is also involved in the regulation of target genes such as PDE7B, DMRT2, and TGFBR3 through interactions with other molecules like circRNAs and miRNAs [PMC7457069]. Overall, hsa-mir-1253 is a versatile microRNA that plays a significant role in various biological processes and disease conditions.