MIR520C: MIR520C is a type of RNA with no homology to any human genomic sequence [PMC7575175]. In a study, MIR520C, along with other candidate targeted miRNAs (miR128 and miR542), was transfected into U251 cells using Lipofectamine RNAiMAX [PMC7575175]. The expression of MIR520C has been associated with metastatic capabilities such as invasiveness and migration in breast cancer [PMC6771808]. Specifically, MIR520C has been found to inhibit breast cancer epithelial-mesenchymal transition (EMT) by targeting STAT3 [PMC5664073]. In breast invasive carcinoma, the cumulative expression of all 46 C19MC miRNA genes, including MIR520C, was analyzed using gene expression data from the miRNASeq dataset [PMC6193703]. Additionally, the TCGA miRNA-seq dataset of liver hepatocellular carcinoma (HCC) was used to obtain cumulative expression data for all 46 C19MC miRNA genes including MIR520C [PMC7378193]. Other studies have reported that MIR520C is involved in regulating osteoblast differentiation and osteomimicry in bone metastasis [PMC6771808] and that increased levels of MIR520C are associated with primary tumors with osteolytic bone metastasis in breast cancer [PMC6771808]. References: - [PMC7575175]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575175/ - [PMC6771808]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771808/ - [PMC5664073]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664073/ - [PMC6193703]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193703/ - [PMC7378193]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378193/