MIR448: MIR448 is a microRNA that has been studied in various contexts. It has been found that the binding sequence for the transcription factor REST is located within the 1 kb region of the MIR448 promoter. Silencing of the REST gene in normoxia leads to an increase in miR-448 expression and a decrease in SCN5A expression [PMC7714400]. Deletion of a specific promoter region from nt -687 to -151 significantly reduces transcriptional activity, indicating its importance for MIR448 regulation [PMC7714400]. MIR448 is located within an intron of the HTR2C gene, but it is regulated independently from HTR2C [PMC7714400]. In various studies, MIR448 has been found to be associated with malignancy and altered expression levels in different tissues [PMC9390975] [PMC6647430] [PMC5768721] [PMC5489807]. It has also been shown to regulate IDO1 and affect CD8+ T cells in human peripheral blood [PMC6686234]. Additionally, MIR448 displays complementarity with hepatitis C virus RNA and has been implicated in miRNA-mediated regulation of immune response and mammary lipogenesis through negative effects on PPARG [PMC4495342] [PMC9780829] [PMC7910866] 21,22[PMID: 4973084][PMID: 8139718].