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hsa-mir-558: The candidate miRNA hsa-mir-558 has been identified in various studies [PMC6948356]. It is significantly downregulated in multiple disease conditions [PMC4268797]. Hsa-mir-558 targets the COX-II and mPGES-1 enzymes, along with other miRNAs such as hsa-miR-101a, hsa-miR-708, hsa-miR-16, hsa-miR-137, and hsa-miR-340 [PMC8452524]. It is predicted to be regulated by MALAT1 and GSDMD [PMC9200665]. Hsa-mir-558 displays length variations with 18 repeats in a significant proportion of MSI cell lines and MSI CRCs [PMC3279428]. Changes in the expression patterns of hsa-mir-558 have been observed after exposure to low and high doses of X-ray in human fibroblasts [PMC3424689].
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