hsa-mir-1208: Hsa-mir-1208 is a microRNA that has been studied in relation to various diseases, including prostate cancer and TNF-α cell group [PMC3140991] [PMC6111343]. In prostate cancer, hsa-mir-1208 was found to be expressed in all tested samples and showed an interesting pattern of expression and interaction with the genotype of rs378854 [PMC3140991]. In the TNF-α cell group, hsa-mir-1208 was down-regulated compared to the control group [PMC6111343]. Hsa-mir-1208 has also been found to be predicted to interact with hsa_circ_0003829 and circNOL10 [PMC7545778] [PMC7780627]. Additionally, hsa-mir-1208 has been identified as one of the down-regulated miRNAs associated with worse overall survival in a study on high-risk signatures [PMC7139587]. However, it is important to note that hsa-mir-1208 was observed as an outlier with an extreme increase in high hazard ratios and was excluded from downstream analysis in this study [PMC7139587]. Further studies are needed to fully understand the role of hsa-mir-1208 in diseases and its potential as a therapeutic target.

MIR1208: MIR1208 is a microRNA gene located at chromosome 8q24.21 [PMC6467893]. It is associated with focal amplifications unique to TCGA, which contain MYC and MIR1208 [PMC6467893]. One of the miR-SNPs in the 3' end of precursor MIR1208, rs2648841, represents a separate signal from the IMSGC GWAS signals [PMC10061723]. Another MIR1208 SNP, rs1861842, has been associated with multiple sclerosis in African Americans [PMC10061723]. Six candidate miR-SNPs associated with multiple sclerosis were identified within the precursor, loop, and seed regions of MIR548AC, MIR1208, MIR3135b, and MIR6891 [PMC10061723]. In pancreatic diseases such as pancreatitis and pancreatic ductal adenocarcinoma (PDAC), downregulation of miR1208 has been observed in patients compared to healthy pancreatic tissue [PMC9599289]. In PDAC patients specifically, alterations in miR1208 were observed at different stages of the disease [PMC9599289]. Furthermore, alterations in miR1208 were also observed between chronic pancreatitis and PDAC patients [PMC9599289]. In a study using the UTSW dataset from cBioPortal for PDAC detection, a panel of 18 microRNAs including MIR1208 exhibited alterations across a majority of PDAC patients sampled [PMC9599289]. Additionally, recurrent copy number changes were observed at chromosome 8q24.21 where MIR1208 is located [PMC2966422]