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Homo sapiens (human) microRNA hsa-mir-298 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-298 precursor URS000069C337_9606

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hsa-mir-298: Hsa-mir-298 is a microRNA that has been identified as a 5ʹUTR CoV-tar-miRNA, along with hsa-miR-1303, has-miR-4645-3p, and hsa-miR-7851-3p, which target AGT mRNAs [PMC8527307]. It has also been found to be associated with prostate cancer (PCa) progression, as its elevation levels can be measured to monitor the progression [PMC5017015]. In the context of multiple sclerosis (MS), the relative expression levels of hsa-mir-298 have been quantified using qPCR in peripheral blood mononuclear cells (PBMCs) of healthy controls and MS patients [PMC6726613]. Hsa-mir-298 is strongly connected to hsa-miR-10b through cancer-specific pathways such as pancreatic cancer, non-small cell lung cancer, chronic myeloid leukemia, cell cycle regulation, and Fc gamma R-mediated phagocytosis [PMC5628841]. It has also been identified as a target of hsa-circRNA_003251, hsa-circRNA_005019, and hsa-circRNA_015115 [PMC5544722]. The circ_3205 sponge effect against hsa-mir-298 may contribute to the progression of SARS-CoV-2 infection by stabilizing the viral genome and triggering biological processes such as inflammation and apoptosis [PMC8763136]. Hsa-mir-298 is predicted to be a 5ʹUTR CoV-tar-miRNA that potentially targets the 5ʹUTR of the SARS-CoV-2 genome [PMC8527307]. In mouse models, viral delivery of hsa-mir-298 has shown efficacy in reducing levels of androgen receptor [PMC8758483]. Additionally, hsa-mir-298 has been found to bind the 5ʹUTR region and its down-regulation has been demonstrated in Alzheimer's disease [PMC8715670].

MIR298: MIR298 is a microRNA that has been identified in various studies. It has been shown to regulate Cu/Zn-SOD expression in response to ROS levels induced by salt stress [PMC9530330]. Additionally, MIR298 is a negative regulator of BACE1 in murine cells [PMC8758483]. It is one of the 24 imprinted genes that were chosen for analysis [PMC6123335]. MIR298 has been found to regulate genes involved in ALA biosynthesis, such as FATA and SAD [PMC5964912]. It is also part of the imprinted GNAS locus, which encodes several transcripts with tissue-dependent imprinting patterns [PMC9716673]. MIR298 expression has been observed to increase with differentiation and is expressed in both mesoderm and endoderm but absent in ectoderm [PMC8713755]. In various studies, MIR298 has been found to be associated with different conditions such as cerebral ischemia reperfusion injury and resistance to antitumor agents [PMC9583544] [PMC9716673]. It has also been implicated in lens development and lens defects associated with Tdrd7-/- mice [PMC7921330]. Furthermore, MIR298 has been linked to Alzheimer's disease and its role in autophagic and apoptotic neuron loss by targeting Act1 has been identified [PMC9583544]

Genome locations

Gene Ontology annotations

Sequence

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UCAGGUCUUCAGCAGAAGCAGGGAGGUUCUCCCAGUGGUUUUCCUUGACUGUGAGGAACUAGCCUGCUGCUUUGCUCAGGAGUGAGCU

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This sequence is found in 2 other species

2D structure Publications