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hsa-mir-920: Hsa-mir-920 is a microRNA that was identified as a possible target for IL-1β in patients with GA. This finding was based on a combination of bioinformatic prediction and miRNA array analysis [PMC5602958]. In addition to hsa-mir-920, four other microRNAs (hsa-miR-30c-1-3p, hsa-miR-488-3p, hsa-miR-550a-3p, and hsa-miR-663a) were also found to potentially target IL-1β and were decreased in the white blood cells of GA patients [PMC5602958]. Hsa-mir-920 is associated with autophagy and targets the autophagy gene ATG9B [PMC9781133]. Other autophagy genes such as ATG12, BECN1, and SESN1 are targeted by different microRNAs (hsa-miR-3064-3p, hsa-miR3675.3p, hsa-miR4797.3p, and hsa-mir6715b.3p) as predicted by Ingenuity Pathway Analysis (IPA) software [PMC9781133]. These findings suggest that dysregulation of microRNAs targeting IL1β and autophagy genes may play a role in the pathogenesis of GA. Further research is needed to elucidate the specific mechanisms involved [PMC5602958] [PMC9781133].
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