Caution, this is an AI generated summary based on literature. This may have errors, see here for more.
Please share your feedback with us.
MIR544A: MIR544A is an oncogene that has been identified in various studies [PMC5983208]. However, its role in peri-implantitis and periodontitis has not been extensively studied [PMC8684662]. Contrary to the results obtained from next-generation sequencing (NGS), quantitative real-time polymerase chain reaction (qRT-PCR) showed a decrease in the expression of MIR544A in PMSII [PMC8684662]. MIR544A has been found to regulate inflammation in spinal cord injury by inhibiting the expression of NEUROD4 [PMC8684662]. These findings provide a valuable reference for further investigation of MIR544A in peri-implantitis and periodontitis [PMC8684662].
To validate the miRNA profile analysis, four miRNAs, including MIR544A, were randomly selected for verification using qRT-PCR [PMC8684662]. Other miRNAs that were commonly found across different profiles included MIR4719, miR6886 (up-regulated), and miR302F, miR579, temire, miR1200, miR548H5, and miR4284 (down-regulated) [PMC8553949]. Among these microRNAs, MIR548ai showed the most significant upregulation relative to MIR544A in smooth muscle cells stimulated with PDGF [PMC8553949].
The interaction between CDH1 and MIR544A was confirmed using a luciferase assay [PMC4051809]. A study focused on two microRNAs - miR-124 and MIR544A - but only measured them in a small population. Further research is needed to determine their diagnostic value on a larger scale population [PMC9436774].
In summary, while there is limited research on the role of MIR544A in peri-implantitis and periodontitis, it has been identified as an oncogene and has been shown to regulate inflammation in spinal cord injury. Further investigation is required to fully understand its significance in these conditions.
Genome locations
Gene Ontology annotations
Ancestor Chart
Loading ontology ancestors...
Failed to load QuickGO Ancestor chart
Sequence
Sequence features are shown above as colored rectangles.
Zoom in and click to view details, or
Reset