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Homo sapiens (human) microRNA hsa-mir-648 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-648 precursor URS000063524F_9606

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hsa-mir-648: Hsa-mir-648 is one of the five overlapping differentially expressed miRNAs (DEMs) identified in the study [PMC8733709]. However, hsa-mir-648, along with hsa-mir-130b, was classified as NRdmiRs, while hsa-mir-659 was classified as a PRdmiR [PMC3059204]. The study found a significant decrease in the expression of hsa-mir-648 in the homozygote rare (TT) genotype in non-tumor tissue [PMC4667940]. The homozygous rare genotype exhibited significantly lower expression of hsa-mir-648 compared to other genotypes [PMC4667940]. This decrease in expression may be attributed to a single nucleotide polymorphism (SNP) in AFF1, specifically rs17703261, which is predicted to disrupt targeting by hsa-mir-648 [PMC4667940]. Hsa-mir-648 is also associated with module #451 in multiple sclerosis according to the study's findings [PMC9618768]. Among four algorithms used for module identification, ClusterONE and MCODE precisely identified module #451 and its associated miRNAs (hsa-mir-599, hsa-mir-572, hsa-mir-614, and hsa-mir-648), while SPICi identified three miRNAs associated with module #451 (hsa-miR599, hsa-miR614 and hasmiR648), and NEMO did not find the module or its associated miRNAs [PMC9618768]. Overall, these references provide insights into the classification of hsa-miR-648 as an NRdmiR along with its significant decrease in expression related to specific genotypes and its association with module #451 in multiple sclerosis.

MIR648: MIR648 is a microRNA that has been identified in various studies. In a study analyzing gene expression patterns, MIR648 was found to be one of the genes that deviated from the diagonal line, along with GHRL, SHANK, and SLC4A10 [PMC9112484]. Another study identified MIR648 as one of the genes with small magnitude changes, along with two other microRNAs (MIR4740 and MIR648) and the DNA binding factor FOXD4L5 [PMC9112484]. However, MIR648 was not detected in baboon liver using miRNA arrays or RT-PCR [PMC2905361]. In relation to MGMT IHC and methylation, it was found that MIR648 is associated with the absence of MGMT methylation [PMC10004383]. Additionally, it was observed that MIR648 and miR6894-5p were positively associated with AR expression in males and were enriched in targets associated with AR expression [PMC9533693]. The decreased translation of MGMT mediated by AR-dependent expression of MIR648 could explain the correlation between high AR expression and longer survival in males with GBM [PMC9533693]. Furthermore, it has been suggested that MIR648 may affect the expression of O-6-methylguanine-DNA methyltransferase (MGMT) similar to miR-181d [PMC7762117]. References: - [PMC9112484]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112484/ - [PMC2905361]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905361/ - [PMC10004383]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004383/ - [PMC9533693]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533693/ - [PMC7762117]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762117/

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AUCACAGACACCUCCAAGUGUGCAGGGCACUGGUGGGGGCCGGGGCAGGCCCAGCGAAAGUGCAGGACCUGGCACUUAGUCGGAAGUGAGGGUG

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2D structure Publications