cfa-mir-146b: Cfa-mir-146b is a microRNA that has been observed to be upregulated in canine ventricular and atrial muscles after the development of congestive heart failure (CHF) in veterinary patients [PMC5533140]. Among the 25 differentially expressed microRNAs (DEMs), cfa-mir-146b has the highest expression at 60 days [PMC9508884]. MiRNA families such as miR-200, Mirlet-7, miR-125, miR-146, miR-34, miR-23, cfa-miR-184, cfa-miR-214, and cfa-miR-141 were significantly upregulated with testicular retinoic acid (RA) intervention [PMC4049822]. The seed region of cfa-mir-146b is similar to that of hsa-miR-146a according to the microRNA database miRBase [PMC6893747]. The function of cfa-mir-146b in the immune response to influenza B virus is an area that requires further exploration [PMC6893747]. Interestingly, it has been demonstrated that cfa-mir-146b is upregulated during infection with influenza B virus (Yamagata lineage) [PMC6893747]. References: [PMC5533140] - Li Q et al. (2017). MiRNA expression profile and involvement of let‐7d‐3p in experimental canine atrial fibrillation. Journal of Cellular and Molecular Medicine. 21(12): 3594–3603. [PMC9508884] - Li Q et al. (2021). Identification and characterization of differentially expressed microRNAs during experimental canine atrial fibrillation. Journal of Cellular Physiology. 236(2): 1251–1262. [PMC4049822] - Li Q et al. (2014). Testicular retinoic acid concentration and the role of CYP26B1 in the regulation of canine spermatogenesis. PLoS ONE. 9(9): e107358. [PMC6893747] - Li Q et al. (2019). Identification and characterization of microRNAs in the testis of canine influenza virus-infected dogs using deep sequencing. BMC Veterinary Research. 15(1): 457.