SNORD107: SNORD107 is a C/D box small nucleolar RNA (snoRNA) located at the 15q11 locus. It is part of a cluster of snoRNAs, including SNORD64, SNORD108, SNORD109a, SNORD115, and SNORD116 [PMC7140444]. Previous studies have excluded the contribution of SNORD107 and SNORD115 to the phenotype of Prader-Willi syndrome (PWS) in humans and mice [PMC2248623]. However, recent research has shown that these snoRNAs share related profiles and are derived from the same transcript [PMC4171697]. The absence of these snoRNAs in PWS patients is associated with deleterious effects [PMC7140444]. In INS-1 cells, Snord116 copies are highly expressed and Snord64 and SNORD107 are also expressed at relatively high levels [PMC10138222]. The upregulation of a specific set of snoRNAs including SNORD64, SNORD107, and SNORD109A has been reported to discriminate between ERG-related and non-ERG-related BCP-ALL samples [PMC8629011]. These snoRNAs play a key role in RNA processing and are involved in PWS development [PMC4630255]. In PWS patients, there is a decrease in expression of the upstream snoRNA SNORD107 by approximately 35% while expression of the downstream Snord115 cluster is increased by approximately 33% compared to wild-type levels [PMC2248623; PMC8037846].