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ssc-mir-328: Ssc-mir-328 is a microRNA that has been identified in several studies as playing a central role in regulatory networks [PMC8614448]. It has been found to be significantly detected in the balanced diet group [PMC8180175]. Ssc-mir-328 has been shown to have more target genes compared to other miRNAs [PMC9453844]. It is also involved in host protective responses and parasite growth [PMC6354428]. Ssc-mir-328 is one of the miRNAs that regulate the production of pro-inflammatory and anti-inflammatory interleukins (ILs) in response to T. gondii infection [PMC8851844]. It is potentially involved in regulating the chemotaxis of immune cells, including neutrophils, lymphocytes, dendritic cells, endothelial cells, eosinophils, monocytes, and leukocytes [PMC8851844]. In addition, ssc-mir-328 is downregulated at 10 dpi and 50 dpi in B cell activation-related pathways [PMC8851844]. It also potentially regulates IL production and plays a pivotal role in IL-mediated signaling pathways triggered by T. gondii infection [PMC8851844]. Ssc-mir-328 has been found to target LRRC8A gene involved in B cell and T cell development [PMC8225432].
References:
[PMC8614448] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614448/
[PMC8180175] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180175/
[PMC9453844] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453844/
[PMC6354428] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354428/
[PM9530237] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530237/
[PMC8851844] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851844/
[PMC8225432] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225432/
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