hsa-mir-4455: Hsa-mir-4455 is a differentially expressed miRNA that has been identified in isolated cancer glands and is associated with both recurrence and non-recurrence in patients with high-grade serous carcinoma (HGSC) [PMC7583725]. It has been found to be upregulated in both HGSCs with recurrence and without recurrence [PMC7583725]. Hsa-mir-4455 is also involved in a single nucleotide polymorphism (SNP) within a lncRNA gene, resulting in a gain of miRNA sites [PMC8287568]. In addition, hsa-mir-4455 has been identified as one of the candidate miRNAs highly expressed in brain tissue and associated with SOD1-ALS, C9orf72-ALS, and the overlap between the two diseases [PMC9951117]. It has also been shown to be negatively regulated by LINC02407, a long non-coding RNA (lncRNA) [PMC6815795]. Luciferase reporter assays have confirmed that LINC02407 directly targets hsa-mir-4455 [PMC6815795]. Hsa-mir-4455 has been found to have tumor suppressive effects in gastric cancer cells [PMC6815795]. Overall, hsa-mir-4455 is a differentially expressed miRNA that plays a role in cancer recurrence, SNP-associated gain of miRNA sites, neurodegenerative diseases such as ALS, and gastric cancer progression.