MACC1-AS1: MACC1-AS1 is a long non-coding RNA (lncRNA) that is upregulated in gastric cancer (GC) and regulates cancer cell metabolic plasticity and stemness through interactions with AMPK/Lin28 signaling [PMC7165246]. MACC1-AS1 enhances glycolysis, contributing to the progression of GC [PMC7162922]. In a recent study, it was found that MACC1-AS1 expression in GC cells is induced by TGF-β1 secreted by mesenchymal stem cells (MSCs) through the activation of SMAD2 and SMAD3 signaling [PMC8579446]. MACC1-AS1 overexpression has been shown to promote cell proliferation, epithelial-mesenchymal transition (EMT), and invasion in hepatocellular carcinoma (HCC) through the regulation of PAX8 [PMC6977655]. Additionally, MACC1-AS1 has been found to potentiate pyruvate kinase M2-driven phosphorylation of NOTCH1 in HCC cells [PMC8220219]. In gastric cancer, inhibition of the TGF-β signaling pathway has been suggested as a potential strategy to suppress MSC-induced stemness and chemoresistance by suppressing MACC1-AS1 expression [PMC7660620]. Knockdown of MACC1-AS1 has been shown to inhibit cell proliferation and increase cisplatin sensitivity in esophageal cancer cells [PMC7819824]. Furthermore, MACC1-AS1 has been found to physically interact with MACC1 mRNA, suggesting a potential regulatory role for this lncRNA in gene expression [PMC5838949]. The expression of MACC1-AS1 is also associated with prognosis in pancreatic cancer [PMC6686482], as well as GC and breast cancer cell lines compared to non-cancerous cells [PMC5838949]. In hepatocellular carcinoma, the silencing or aberrant expression of MACC1-AS1 affects cell cycle progression and apoptosis rates [PMC6686482].