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hsa-mir-4454: Hsa-mir-4454 is consistently higher in obesity compared to thin individuals [48]. Hsa-miR-582-5p is down-regulated in the visceral adipose tissues-derived exosomes of obese patients [49] [PMC9933125]. Some hsa-mir-4454 reads display heterogenous 5' ends that differ from the annotated genomic locus, but match the sequence of tRNAHis [PMC6675128]. Hsa-mir-4454 and hsa-miR-7975, which were validated in a discovery cohort, failed to validate in an independent patient cohort [PMC7708817]. Hsa-mir-4454 is up-regulated in plasma-derived exosomes from normal Bactrian camels, along with other differentially expressed miRNAs and proteins [PMC9933125]. Hsa-miR-762 is predicted to target Mapk3 and Mapk1, while Fos is predicted as a target of hsa-mir-4454 and rno-miR-144-3p [PMC5709462]. Predicted targets of hsa-mir-4454 include IL10, IL1R1, IL13RA1, IL18BP, IL10RB, and CCR4 [PMC8686203]. Hsa-mir-4454 and hsa-miR7975 have potential diagnostic value in breast cancer cells according to ROC analysis [PMC7005890].
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