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SNORD94: SNORD94 is a C/D box scaRNA that targets a cytosine at position 62 (C62) on spliceosomal RNA (snRNA) U6 for 2’-O-methylation [PMC6894857]. In a study comparing gene expression in Tetralogy of Fallot (TOF) patients, SNORD94 was found to be one of the top downregulated genes [PMC9622801]. SNORD94 is involved in U6 snRNA modifications, which are important for spliceosomal function [PMC6023535]. In cell culture experiments, the change in SNORD94 expression was the only difference observed in knockdown and overexpression experiments [PMC6894857]. The expression level of SNORD94 was confirmed using qRT-PCR [PMC6894857]. In B cells, SNORD94 expression is reduced compared to other B cell types, suggesting its role in B cell maturation and function [PMC10050728]. The interaction between regRNP17 and SNORD94 disrupts the interaction between SNORD94 and U6 snRNA [PMC6124571]. Methylation at C62 on snRNA U6 is reduced in right ventricle tissue of children with TOF compared to control, suggesting a link between levels of SNORD94 and levels of C62 methylation [PMC6894857]. The study hypothesizes that proper expression levels of SNORD94 and other scaRNAs are important for spliceosomal function and may play a role in regulating heart development [PMC6894857].
mRNA interactions
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