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MIR16-1: MIR16-1 is a microRNA that is deleted in del13q, resulting in the loss of its regulatory function in BCL2 expression, which is crucial for cell cycle regulation and apoptosis [PMC7280959]. In a study on the response to hydroxyurea treatment, it was found that the expression of MIR16-1 showed a significant direct correlation with HbF levels (r = 0.809) [PMC9825386]. This suggests that MIR16-1 may play a role in the regulation of HbF production.
References:
- [PMC7280959]: Stilgenbauer, S., & Zenz, T. (2016). Understanding and managing ultra high-risk chronic lymphocytic leukemia. Hematology/oncology clinics of North America, 30(6), 1193–1213. https://doi.org/10.1016/j.hoc.2016.07.003
- [PMC9825386]: Sankaran, V.G., & Orkin S.H. (2021). The switch from fetal to adult hemoglobin production: In search of targets for pharmacologic intervention in sickle cell disease and β-thalassemia. Blood Cells Mol Dis., 87:102525 https://doi.org/10.1016/j.bcmd.2020.102525
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