LINC01414: LINC01414, a long intergenic non-protein coding RNA 1414 located at chromosome 8q12.3, has been studied in relation to chronic obstructive pulmonary disease (COPD) in the Chinese Han population [PMC8261955]. In this study, three single nucleotide polymorphisms (SNPs) in LINC01414 and LINC00824 were analyzed [PMC8261955]. The SNPs rs699467 and rs7815944 in LINC01414 were associated with a lower prevalence of COPD, while the SNP rs298207 in LINC01414 was associated with an increased risk of COPD [PMC8261955]. The study also revealed an additive effect between the SNPs rs6994670-GG and rs298207-AA in LINC01414, as well as the SNP rs7815944-GG in LINC00824, on COPD susceptibility [PMC8261955]. Specifically, the SNP rs699467 was found to be a protective factor for COPD occurrence under dominant and additive models [PMC8261955]. However, no statistically significant association was observed for the SNPs rs6994670 and rs298207 in LINC01414 [PMC8261955]. The prevalence of the G-allele frequencies of SNP rs6994670 in LINC01414 was lower in COPD patients compared to controls [PMC8261955]. The function of LINC01414 has not been reported yet [PMC8261955]. In conclusion, this study suggests that certain SNPs within LINC01414 and LINC00824 may play a role in COPD risk among the Chinese Han population. However, further research is needed to fully understand the mechanisms involved [PMC8261955].