hsa-mir-659: Hsa-mir-659 is a non-regulated microRNA that has been investigated in cell lines and has been shown to influence the risk of dementia [PMC4222942] [PMC3448685]. The joint contribution of H1F0 and hsa-mir-659 on the risk of dementia is a topic that may require further attention [PMC3448685]. It is possible that the detected interactions between HLA-DPB1 and hsa-mir-219-1, as well as between H1F0 and hsa-mir-659, may be tagging for other complex haplotypic effects spanning a large distance and involving several genes [PMC3448685]. Two interactions involving miSNPs × 3utrSNPs have been robustly identified, one involving HLA-DPB1 rs1042448 and hsa-mir-219-1 rs107822, and the other involving H1F0 rs1894644 and hsa-mir-659 rs5750504 [PMC3448685]. In a study on Burkitt lymphoma cases, it was found that hsa-mir-659 differentiated cases based on Epstein-Barr virus (EBV) status, while 21 EBV-encoded miRNAs were differentially expressed in the two categories [PMC4807994]. Additionally, hsa-mir-659 was found to be part of a predictive signature for recurrence-free survival (RFS) in another study [PMC9221286] [PMC6682788]. It was classified as a predictive miRNA (PRdmiR) in one study but classified as non-responsive (NRdmiR) in another study [PMC3059204]. The folding energy of the interaction between hsa-miR-185* and TrkB-T1 3′UTR was estimated to be similar to other microRNA interactions investigated [PMC3382618]. According to miRBase annotation, hsa-mir-659 encodes a mature miRNA at its 3p arm [PMC3303722].