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Homo sapiens (human) long intergenic non-protein coding RNA 1567 (LINC01567) URS00005467C8_9606

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LINC01567: LINC01567, also known as LOCCS, is a long intergenic non-protein-coding RNA (lncRNA) that is overexpressed in colon cancer stem cells (CSCs) [PMC5674857]. It is located on chromosome 16 and consists of three exons, producing a 2907 bp transcript [PMC5674857]. LINC01567 has been found to be upregulated in colon cancer-derived spheroid cells and CSCs [PMC5674857] [PMC10136834]. It has been shown to promote proliferation in CSCs by sponging miR-93-mediated tumor suppression, and its knockdown reverses this effect [PMC10136834]. LINC01567 is predicted to sponge several miRNAs in cancer cells to promote proliferation [PMC10136834]. It has also been found to enhance the proliferation of colorectal cancer stem cells (CRCSCs) and tumorigenesis by targeting microRNA-93 and upregulating MSI1 [PMC8829571]. LINC01567 has been implicated in the occurrence and metastasis of colorectal cancer (CRC) [PMC6131861] [PMC6286632] and its inhibition suppresses the proliferation, migration, invasion, and tumor xenografts of colon CSCs by sponging miR-93 [PMC7697375]. Dysregulation of lncRNAs, including LINC01567, has been observed in CRC, with lncRNAs playing critical roles in tumorigenesis through various mechanisms such as miRNA-mediated gene regulation and mRNA stability control. They have also been implicated in chemoresistance pathways. NEAT1 was identified as a diagnostic biomarker for CRC prognosis. Another lncRNA u50535 was found to be associated with adverse prognosis in CRC patients.

Genome locations

Gene Ontology annotations

Sequence

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AGUGCUGUCGGAGGGUUGCUGGGGAAAGGAGAUUGGCUGGCGAGGAAGAUGAGGAAUGUGCUGCCAGGAGACUGGGAUCACGGCCAGAUGCUAAUUACGAUGGCCUGGGGGUGCUGGUACCCCCUGUCAGCAUCAUAUCAGCCUCUCCACUUCAAAUCCUGCCCCUCUGAUGUUAGAAUCUGGCUGCAACCAUCCCGUGAUUCUGUGGAGCCUCGUGCCUUACUUCUGCUGGCUUCUGUCUGUCGUCACUUCCGUUCUCCACCACCCUGGCCUCAAUCAAACACGUUUUCUCUGAUGCAAAACUCGACCUUCAUUUACAGAAAGGGUUAUCUCAAGAGGCUUGGGAUGGUUAAACCCUGCACAUCUCAGAGGAAGGACUGGCUCUUCACCUGUUCCUGCAGGAUAACUGCUAACGGCUUAAAAUAUUCUGCCUGAUAAGAGGGCUUCUGUAUAUCUGGGGCCUUGGGCCAUGCCGGGUAGUUGAUGCUAACAACAUGAUUUAUGGUGGGUGCCUGCGGUCAUGCUGUAUCAGCCUGACCUCUGGAGGGGCUGGACACUGGGUAACUGAUCCCCAAGAAAAGCCAUGGACACUAAGGCUCAGGUGAGUUCCCCUGGUUGGCAGUGUUUUGCGUGUGUUGUCACACAUCAUUGCUGGGAGACUUAAGCACUGCACAUAUGACUAUCUAGGAGGGUACAGCUGCAAGCUCCUGCCUGGAUUCUGCCCUGAGCACCUUUUUCCUUUGCUGAUUUUGUUUAUCUAUUUAUUUAUUUUUGAGAUGGAGUCUCACUCUGUCACCAAGGUUGGAGUGCGGUGGCUGGAUCUCGGCUCAUUGCAACCUCCACCUCCCAGGUUCACGUGAUUCUUCUGCUUCAGCCUCCCAAGGAGCUGGGAUUACAGGUGCCAACCACCAUGCCUGGCUAAUUCUUAUAUGUUAGUAGAGACGGGGUUUUGCCAUGUUGGCCAGGCUGGUCUCGAACUCCUGAGCUCAAGUGACAAGGCCGCCGGCCUCGACCUCCCAAAGUGCUGGGAUUACAGGCAUGAGCCACCGCGCCUGGCCCCUUUGCUGAUUUUUAAUCCGCAUCCUUCCACUGUGUUAAGCUGUAACUGUGAAUACAACAGCUUUUUUGAGUUCUGCGAUUCUUUGCAGCAAAUCGUCAUACCUGAGCGUGUCUUGGGGACUCCCCGACACAUCUUCCCACUCCCUCUUCUGUUUUCUCACUUCCUCUGGAGUAAACUGAAAGAGGCCCCUGCUUGCCUCUUGCAAGGCAGUUCUGAACACACUGAGAUCAUUUGUGAUCUCAUAUCCUCUUCUAAGCAAUUCAUCAAGAAAUUUCUUUCAAAUAAACCCAGUGCUCUUCAUGGAGGUGAUGCUGAUGAAAAUGACUUUCUCCAGCUUAUUACACGUUUGCAGAAGCUCCUGUUUAAGAGUUUGAGCAUGUAUGUGUGUGUGCAUAUACACCAGCACACACAUGCAUGCCCACAGCUGUCAUGCCUUCACCAGAACCAGGACGAGGAGUUAUUCUAUUGCCAGAAUUGAAGAACCAUUUCCACAUAUUGUAAGGUCAGUGAAAGUACAAUGAAAAAUACACCUGCUAGCAUGCCUAUGCAUGGCCUCUCUGCAAAUAAGAUGAAGGUCCCUUCACCACCUGCUUGCACUGCUAAUGGCCCUGUAGAUUCCACUGGAUGGAUUUGUAAUUUUCUCAACCAUUUCCCCUAAUGCUGGAUAUUUGGGUUAUUUCCAACAUUUUUACGCUUCCAAAUAAGGCACCCAUAAUGAUUCUUGCAGAGUAAUCAUUAGGCUCUUCUAUAAUUAUCUAAUUAUCCUUUUUUUUUUGUUUUUUUCUGAGGCAGGGUCUUGCUCUGACACCCAGGCUGGAGUACAGCGGCACGAUCAUGGCUCACUGCAGCCUCAGCCUCCCACGCUCAAGUGAUUCCACAGUCUCAGCCUCCUGUGUAGCUGGGAUCACAGGUGUGCGCCACCACGCCUGGCUAACUUUUUGUACUUUUUAUAGAGACGGGGAGUUUUUUUGUAUUUUUUUAAAUAGAGACGAUGUCUCACCAUGUUGCUUAGGCUGUUCUGGAACUUCUGGACUCCAGUAAUCCUCCUGCCUCAGCCUCCCAAGGUGCUGAGACUAUAGGCAUGAGCCACCGUGCCCAGCCAUAUAAUUAUCUUAAGAUAAAUUUCUAUACAUGGAAUUUUUAUACGUGGAAUUUCUAUACAUGAAUUAAAGAGCACAGAUUUUUGUAUGUUGGUUGCUUGGUUUUUAGAGGCAGUAUCUCACUCCAUUGCCCAGGUUGGAGUGCAGUGGUGCAAUCAUAGCUCACCGCACCACUGAAUUCCUGGGCUCUAGGAGUCCUCCUUCCUCAGCCUCCUAAGCAACUAGGACUACAGAGUACAUAUGUUUUUAAGAUCUUUGAUAUCUUAUACCUUUUGGGGACUGUAUCAGUUAAAAACUCUACCAGUACUGUAGAAACAUGAUCGUGUCUCUGUUUCCUUGCCACACUGGGCAUUAAUUACUUGAUCCAUUAAUGAGUUAAUUGCACCCUCAAUAAGAGUAUGGUAAAGUGUGACACAUUUACACUACAGAAUAUUAUGCUGUAAAGAAUAAGGAUGUAGGCCAGGUGAGGUGGCUCAUGCCUGUAAUCCCAGCACUUUGGGAGGCCGAGGCGGGCGGAUGACGAUGUGAAGAGAUCGAGACCAUCCUGGCCAACAUGUUGAAACCCCGUCUCUACUAACAGUACAAAAAUUAGCUGGGUGUGGUGGCAGGUGCCUGUAAUUCCAGCUACUCGGGAGGCUGAGGCAGAAGAAUCGCUUGAACCUGGGAGGCGGAGGUUGCAGUGAGCCAAAAUGGCGCUACUGCACUCCAGACCGGGGACAGAGUGAGACUCUGUCUCCAAAACAAAAC

Taxonomic tree

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Expression New Publications