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Homo sapiens (human) long intergenic non-protein coding RNA 1393 (LINC01393) URS000052A30B_9606

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LINC01393: LINC01393 is an intergenic long non-coding RNA (lncRNA) located on chromosome 7q31.2, and its pathophysiological function is currently unknown [PMC10056594]. However, recent research has shown that LINC01393 plays a critical role in the progression of glioblastoma (GBM) [PMC10056594]. Through in vivo and in vitro experiments, it has been demonstrated that LINC01393 acts as a sponge for miR-128-3p and rescues the expression of NUSAP1, thereby promoting glioma progression [PMC10056594]. Knockdown of LINC01393 has been shown to decrease the phosphorylated p65 level, while overexpression of NUSAP1 can reverse this effect [PMC10056594]. These findings provide strong evidence suggesting that LINC01393 promotes NUSAP1 expression by inhibiting miR-128-3p, and the LINC01393/miR-128-3p/NUSAP1 axis may significantly contribute to GBM progression [PMC10056594]. Furthermore, qRT-PCR analysis of 18 GBM samples confirmed the correlation between LINC01393, miR-128-3p, and NUSAP1 expression levels [PMC10056594]. In addition to this clinical evidence, analysis of glioma specimens from mice also confirmed that NUSAP1 expression was downregulated with a decrease in LINC01393 levels [PMC10056594]. Moreover, overexpression of LINC01393 was significantly correlated with a poor prognosis for glioma patients according to data from The Cancer Genome Atlas (TCGA) database [PMC10056594]. The abundance of LINC01393 was found to be relatively lower in U251-MG and T98G cell lines compared to other cell lines studied [PMC10056594]. To further investigate the function of LINC01393, the full-length human LINC01393 cDNA was synthesized and sub-cloned into a lentiviral vector for experimental manipulation [PMC10056594].

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Sequence

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AAGUGUCCUGUUAUUAAAGGGAGUUUGACCCUCUCUUGCUGGCUUGCUCUCAUGCUUUCUUGUCCUUCUGCCUUCUGCCAUGGGAUGACACAGCAAGAAGCCCCUUGCCAGAUGUGGGCCUCUCGACCUUGGACUUCUUAGCUUCCAGAACUAGGAGCCAUUGAAGAAUACUGUUGUCCUAUCCCAGAAGGAGCAAGCGGACAACACUGAUAUCCUGACCACUAACCAUCCAGCACCACUUAAAGUUUUAAAAAGAAUAACAGAAAGAAAGAAGUGGCUGAAACCUAAAUGCCAUAUGGAGAAGACAGCUAAUUGCCACACUCUCCUCUUUGGUCUUUCCUGGUACGCAGCAUACAAGCCCACAGAUUGAGGACUCUGCACUUGCUGUUCUCUCUGCCUGGAGCUCUAUGGCUCCAGAUAGACUCCUGCCAACUCCUUCGCCUUGUCCAAGUUACCUUCAUUAAAUGUCAGCUUAAAUGUGUGCCUACUUUUUGCCCUACCUAGAAUUGCAAGCACCUCUCACCACUGUGCUCCCAUUCUCCUUAACUUAAGCCACUUUUAUUCUCAUAAUAAAGCCACAUAUUUUUUCUUAUUAUAUCAUAAUCGUACUGUAUAAUUUAUAUUUUAUUACUUUUGUUUGUAUACUUAUUGUAUGUUUCUGUUCACAAGGAUGUAAACCCCAUGAACACAGAGAUCUUUGAUUGUUUUAUUCACUGAUUUAUGCCAAAUGUUUGGAACAAUGCCUGGCACAUAGUAGAUGUUUGAUAAUUUUUUUUUUUUCUGAAUGAAUAAAUACAUUUUAGCCAAAUAUGCUGACUCUGCUUGUUUGGUUAUAUUUAUGUGUGUGUGAAUGUAUGUGCAGAAAAAGAAGAAAUUAGUUAAUACCAAAUCUAUAAAAUGGGAAAAAUAAUGCUUACCUUAUAGUGUUGUUAUGAAACUCAACUAAUAUAAGAUAUGUGAAGGGUCUAGCAUAAAAUGUGGAGCAUAAUAAGCAUUCAAUAAAUGGCAUUCUGUUUUAUUAACCAUCUGGUUGCCUAUUGUUGAAGGUCGGCUCUUUAAUGUGCAAAUUAAGGUGUUUUAUUUCCUUCAUAUAUCAAUUAUAGUCUGUUUAUUUACUUCUAGAUAAAAUCCUUUGAUGGACAUUUAAGCUGUGCCAACUAUUUACUAAUAAAAAUAUUUACAUUCUG

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