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cfa-mir-30b: Cfa-mir-30b is a microRNA that has been analyzed in the plasma of Dachshunds with mitral valve disease (MMVD). Two studies have identified cfa-mir-30b as a significantly downregulated miRNA in dogs with MMVD, specifically in Stage B and dogs with moderate cardiac enlargement [PMC4490541] [PMC4964495]. Another study found that cfa-mir-30b, along with cfa-miR-133b, regulates connective tissue growth factor, which is important in the development and progression of canine mitral valve diseases [PMC7924183]. Cfa-mir-30b was also selected for validation in a microarray study along with other miRNAs [PMC5678797]. Furthermore, the downregulation of cfa-mir-30b and cfa-miR-133b has been observed in plasma miRNA analysis of Dachshunds with MMVD [PMC5533140]. In a previous study, dysregulation of cfa-mir-30b was found only in MMVD Stage B dogs compared to healthy dogs [PMC8542680]. Additionally, adrenal cortex samples have shown that cfa-miR-30 family (including cfa-miR-30a, cfa-mir-30b, cfa-miR-30c, and cfa-miR-30d) is among the most abundant known miRNAs [PMC4768678]. Overall, these studies highlight the significance of downregulated expression of cfa-mir-30b in MMVD and its potential role as a biomarker for disease progression.
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