mmu-mir-146b: Mmu-mir-146b is an up-regulated miRNA that is associated with various biological processes and diseases. It has been observed to be up-regulated in response to HFD-induced obesity and S. japonicum infection [PMC3319598] [PMC3692539]. The upregulation of mmu-mir-146b in S. japonicum-infected mice may reflect the recruitment and activation of B and T lymphocytes in response to antigens secreted by the eggs [PMC3692539]. LNA-containing primers were designed to quantify mmu-mir-146b, along with other hard-to-amplify miRNAs, in order to overcome technical challenges [PMC3030602]. In silico analysis has also shown significant correlations between mmu-mir-146b and modulations of mRNAs related to apoptosis processes [PMC3030602]. Mmu-mir-146b has been found to regulate the NFkB signaling pathway, indicating its involvement in immune responses [PMC4077261]. It has also been observed that mmu-mir-146b is significantly up-regulated during mid-phase infection with S. japonicum [PMC5390025] [PMC3692539]. Mmu-mir-146b is one of the 22 murine microRNAs selected for qPCR validation of their expression, indicating its importance in various biological processes [PMC3319598]. Mmu-miR-21, mmu-let-7c, mmu-miR-146a, and mmu-miR-378 are among the most abundant miRNAs along with mmu-mir-146b in both libraries studied [PMC3421232].