hsa-mir-4443: Hsa-mir-4443 is a microRNA that has been studied in various diseases. In patients with AF, hsa-mir-4443 was found to significantly decrease compared to control, suggesting its potential as a diagnostic and molecular biomarker [PMC7931814]. In a study comparing plasma samples from patients with Kawasaki disease (KD) and control groups, hsa-mir-4443 was found to be significantly downregulated in the KD plasma samples [PMC5780174]. This downregulation of hsa-mir-4443 in KD is consistent with its role in other diseases where it is upregulated, such as acute ischemic stroke, central nervous system tumors, and drug-resistant non-small cell lung cancer [PMC7931814]. Additionally, the study identified other miRNAs that were significantly upregulated (hsa-let-7b-5p, hsa-miR-223-3p, hsa-miR-4485, hsa-miR-4644, hsa-miR-4800-5p, hsa-miR6510 -5p and has -miR -765) or downregulated (hsa -miR -33b -3p and hasa miRNA 4515) in the KD plasma samples compared to the control group [PMC5780174]. These findings highlight the potential role of miRNAs as biomarkers for various diseases.