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bta-miR-133a: Bta-mir-133a is a microRNA that has been identified in various studies and has been found to have different target sites in different contexts [PMC7230347] [PMC7653039]. It has been implicated in various biological processes, including cancer suppression [PMC9343836]. In the context of cadmium-induced BMEC model, bta-mir-133a has been shown to function as a sponge for circRNA-08409 and target TGFB2 [PMC9707628]. Bta-mir-133a has also been found to be expressed in mammary tissue samples of Holstein cows and is associated with other miRNAs such as bta-miR-21-5p, bta-miR-99a-5p, bta-miR-146b, bta-miR-145, and bta-miR-2285 t [PMC8520644]. It is considered a muscle-specific miRNA in bovine and its expression levels have been reported to be 689 RCPM [PMC5003961]. In the context of postpartum transition, the expression of bta-mir-133a was found to be downregulated along with other miRNAs such as bta-miR144 and bta-miR378c [PMC9445238]. In another study, the expression of bta-mir-133a was increased in heat-stressed cows [PMC6309072]. Bta-mir-133a has also been implicated in the regulation of skeletal muscle development by inhibiting the expression of Pax7 through binding with LOC104975788 [PMC9149217]. Furthermore, it has been shown to be involved in regulating the NF-kappa B signaling pathway along with other miRNAs such as bta-miR214 and bta-mir1246 [PMC6600136]. Overall, bta-mir-133a is a versatile microRNA that plays a role in various biological processes in bovine.
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