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Homo sapiens (human) small nucleolar RNA, H/ACA box 56 (SNORA56) secondary structure diagram

Homo sapiens (human) small nucleolar RNA, H/ACA box 56 (SNORA56) URS00004C6FD8_9606

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SNORA56: SNORA56 is a small nucleolar RNA (snoRNA) that has been found to be differentially expressed in various biological contexts. It has been reported to be downregulated in one group and upregulated in another [PMC7206725]. SNORA56 is a Dicer substrate and has been identified as a Dicer substrate within mRNA introns and exons [PMC8184798]. It is also known to modify specific positions on rRNA molecules [PMC6466398]. SNORA56 is hosted by the DKC1 gene, which is associated with X-linked dyskeratosis congenita (X-DC) [PMC6466398]. In X-DC patients, SNORA56 has been found to be downregulated in fibroblasts or lymphoblast cells expressing mutant DKC1 [PMC6466398]. SNORA56, along with other snoRNAs, has also been identified as being differentially expressed in colorectal cancer (CRC) tissues [PMC7559222]. In addition, SNORA56 has been found to be upregulated in both proliferating normal B-cells and proliferating chronic lymphocytic leukemia (CLL) cells, suggesting its functional relevance for proliferation [PMC9219770]. Furthermore, SNORA56 has been identified as part of an optimal H/ACA snoRNA signature for the identification of high-grade serous ovarian cancer (HGSC) tissues [PMC8759569]. It can discriminate between HGSC and serous borderline tumor (SBT) tissues independently of its host gene expression [PMC8759569]. The knockdown of SNORA56 did not affect cell growth under the tested conditions, suggesting that it may function as a marker rather than directly contributing to cell growth [PMC8759569].

Genome locations

Gene Ontology annotations

Sequence

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CGGCAGACAGUUAUCCCUUUCUAGUCUGGCUCGUGGGACUCUAGAGGGAGUCAGUCUGCAACAGUAAGUGGUGAGUUCUUCUGUCCAGCGUCAGUAUUUUGAUGGUGGCUUUAGACUUGCCAGAUAACA

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This sequence is found in 1 other species

2D structure Publications