MIRLET7A3: MIRLET7A3 is a gene that belongs to the MIRLET7A gene family, which also includes MIRLET7A1 and MIRLET7A2 [PMC7459851]. It is located at 22q12.31 within the MIRLET7BHG gene [PMC6353855]. The hypermethylation of the MIRLET7A3 gene has been reported in various cancers, including acute myeloid leukemia, ovarian cancer, and breast cancer [PMC6353855]. In hepatocellular carcinoma (HCC), the CpG island in the MIRLET7A3 gene is hypermethylated compared to healthy liver tissue [PMC6353855]. The deletion of the 22q13.31 region where MIRLET7A3 maps is frequently observed in ovarian tumors [PMC5400605]. In breast carcinomas, hypermethylation of the super-enhancer region associated with MIRLET7B and MIRLET7A3 leads to their transcriptional silencing [PMC4728783]. The array Comparative Genomic Hybridization study identified three genes expressing let-7a: MIRLET7A1 on 9q22.3, MIRLET7A2 on 11q24.1, and MIRLET7A3 on 22q13.3 [PMC5356719]. A custom gene panel was designed to include microRNA genes such as MIR100, MIRETLETA1-2-3-B-C-D-E-F-G for mutation profiling of pediatric cancers [PMC7341754]. Mutations in IL6 and LIN28a genes were also investigated but no mutations were found in these genes associated with IL-6 regulatory pathway [PMC3601972].