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hsa-mir-532: Hsa-mir-532 is a microRNA that has been found to be involved in various biological processes and diseases. It has been shown to suppress migration and proliferation in renal cell carcinoma (RCC) by targeting insulin-like growth factor 1 receptor (IGF1R) and nucleosome assembly protein 1-like 1 (NAP1L1) [PMC8490801]. In a study that analyzed differentially expressed microRNAs in RCC, hsa-mir-532 was found to be down-regulated [PMC5041965]. It has also been identified as a potential biomarker in different studies [PMC8844910]. In pancreatic islets, hsa-mir-532 exhibited lower DNA methylation and higher expression levels in females compared to males [PMC4256841]. Furthermore, hsa-mir-532 has been shown to target genes involved in the Gata3 signaling pathway [PMC4359317]. In patients with complex regional pain syndrome (CRPS) Type-2, higher levels of hsa-mir-532 were observed compared to CRPS Type-1 patients [PMC3228853]. Additionally, hsa-mir-532 was found to be significantly associated with overall survival in various cancer types, including breast cancer and pancreatic ductal adenocarcinoma (PDAC) [PMC7897818] [PMC9780260] [PMC8613738]. It has also been identified as differentially expressed between normal and tumor cells in multiple myeloma-associated vasculopathy (MMVP) specimens [PMC4881574]. Hsa-mir-532 is clustered with other microRNAs such as hsa-mir-188, hsa-mir-362, and hsa-mir-660 [miRDB] and has opposite effects on proteins like NF-kB compared to other influenza viruses.
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