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ssc-mir-15b: Ssc-mir-15b is a microRNA that has been studied in various contexts. It has been found to be upregulated in E. coli F18-sensitive pigs, as well as in pigs susceptible to E. coli F18 infection [PMC3427155]. It is also expressed in various pig tissues, including the brain, liver, heart, muscle, colon, kidney, lung, spleen, stomach, cervix and fibroblasts [PMC3427155]. In addition to its role in infection susceptibility and tissue expression patterns, ssc-mir-15b has been implicated in the regulation of lipogenesis and the expression of certain genes. It has been reported to have different expressions between lean and obese pig breeds [PMC7552122]. Furthermore, ssc-mir-15b has been predicted to bind to the 3' UTR of the arresting domain containing 3 (ARRDC3) gene [PMC10159129]. The upregulation of ssc-mir-15b may be linked to a low n-6/n-3 PUFA ratio and the production of anti-inflammatory metabolites [PMC10159129]. Additionally, ssc-mir-15b expression can be inhibited by certain compounds such as SFN (sulforaphane) [PMC9179638]. Overall, ssc-mir-15b is a versatile microRNA that plays a role in infection susceptibility, tissue expression patterns, lipogenesis regulation and gene expression regulation.
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